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September 1, 1999HeartOpen Access

Plaque erosion is a major substrate for coronary thrombosis in acute myocardial infarction

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Population

298 consecutive patients dying in hospital between 1984 and 1996 from acute myocardial infarction, not…

Design

Cross-sectional

Authors

EAEloisa ArbustiniBBBarbara Dal BelloPMPatrizia Morbini

Discussion

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Overview

Higher plaque erosion in women with fatal MI may inform sex-specific evaluation; extends pathological insights but leaves open therapeutic implications.

Structured PICO

P
Population
298 consecutive patients (189 men, mean age 66 years; 109 women, mean age 74 years) dying in hospital between 1984 and 1996 from acute myocardial infarction, not treated with thrombolysis or coronary interventional procedures.
O
Outcome
Histopathological determination of plaque erosion as substrate for acute thrombosis; location and histological type of coronary thrombosis; acute and healed myocardial infarcts; ventricular rupturesurrogate

Plaque erosion is a major substrate for coronary thrombosis in fatal acute myocardial infarction, with a significantly higher prevalence in women compared to men.

Cite This Study

Arbustini et al. (1999) studied this question.

synapsesocial.com/papers/6a2fa7a080b8ef8aeb5c6bddhttps://doi.org/10.1136/hrt.82.3.269
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Effect of Risk Factors on the Mechanism of Acute Thrombosis and Sudden Coronary Death in Women1998 · 437 citations
  2. 2Plaque rupture with severe pre-existing stenosis precipitating coronary thrombosis. Characteristics of coronary atherosclerotic plaques underlying fatal occlusive thrombi.1983 · 1,015 citations
  3. 3Localization of stromelysin gene expression in atherosclerotic plaques by in situ hybridization.1991 · 594 citations
  4. 4Pathology of acute myocardial infarction with particular reference to occlusive coronary thrombi.1976 · 273 citations
  5. 5Differential Expression of Tissue Factor Protein in Directional Atherectomy Specimens From Patients With Stable and Unstable Coronary Syndromes1995 · 212 citations