Key result
Implementation of polarization sensitivity with synchronous fluorescence spectroscopy improved the significant difference of evaluated parameters for differentiating cancerous and healthy tissues.
Why the study?
Does the implementation of polarization sensitivity with synchronous fluorescence spectroscopy improve the differentiation of ex vivo colorectal tissue samples compared to SFS without polarization?
Does the implementation of polarization sensitivity with synchronous fluorescence spectroscopy improve the differentiation of ex vivo colorectal tissue samples compared to SFS without polarization?
Adding polarization sensitivity to synchronous fluorescence spectroscopy improves the differentiation between cancerous and healthy ex vivo colorectal tissues.
Answers are grounded in this paper and cite their sources.
May support photonic tissue differentiation; leaves open prospective human validation from animal ex vivo data.
In the present work the possible benefits of implementation of polarization sensitivity with synchronous fluorescence spectroscopy for differentiation of ex vivo colorectal tissue samples was evaluated. Synchronous fluorescence spectroscopy (SFS) is superior method for fluorescence analysis in comparison with standard fluorescence spectroscopy. Parallel and perpendicular linear fluorescence polarization, in respect to the polarization of the excitation light, was additionally applied with SFS. Same parameters based on the area of the most prominent fluorescence maxima for SFS without polarization, with parallel and perpendicular polarization, were compared. The introduced polarization sensitivity improves the statistically significant difference of some of the evaluated parameter for cancerous and healthy tissues and their potential application as diagnostic criteria.
No takes yet. Share an insight, caveat, or question.
Genova et al. (2018) studied colorectal cancer. Synchronous fluorescence spectroscopy with polarization sensitivity vs. Synchronous fluorescence spectroscopy without polarization sensitivity was evaluated on differentiation of cancerous and healthy tissues. Implementation of polarization sensitivity with synchronous fluorescence spectroscopy improved the significant difference of evaluated parameters for differentiating cancerous and healthy tissues.
Synapse has enriched 10 related papers. Consider them for comparative context: