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January 26, 2007HepatologyOpen Access

Fibroindex, a practical index for predicting significant fibrosis in patients with chronic hepatitis C

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Authors

MKMasahiko KodaKomagino HospitalYMYoshiko MatunagaTottori UniversityMKManri KawakamiOkayama Saiseikai General Hospital

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Overview

Cohort study demonstrates that FibroIndex accurately predicts significant fibrosis in chronic hepatitis C, indicating routine blood markers can reduce the need for liver biopsies.

Key Points

  • Develop and validate a noninvasive scoring index using standard laboratory parameters to predict significant liver fibrosis and monitor treatment response in patients with chronic hepatitis C.
  • Divided treatment-naive chronic hepatitis C patients who underwent liver biopsy into an estimation set (n = 240) and an independent validation set (n = 120).
  • Calculated the FibroIndex model using routine measurements of platelet count, aspartate aminotransferase (AST), and gamma globulin levels, comparing accuracy against the Forns index and APRI.
  • Evaluated longitudinal changes in a subset of patients (n = 30) who received liver biopsies before and after interferon treatment.
  • FibroIndex yielded an area under the ROC curve for predicting significant fibrosis of 0.83 in the estimation set and 0.82 in the validation set, outperforming the Forns index and APRI.
  • Optimal diagnostic cutoff values allowed 35% of patients to avoid liver biopsy with high positive predictive values.
  • In the longitudinal cohort, FibroIndex decreased significantly in 14 patients with improved fibrosis and increased significantly in 5 patients with deteriorated fibrosis, correlating with histologic changes whereas APRI and Forns did not.

Cite This Study

Koda et al. (2007) studied this question.

synapsesocial.com/papers/6a157c029b87f33fc69f9903https://doi.org/10.1002/hep.21520
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Also Consider

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  1. 1A Simple Noninvasive Index Can Predict Both Significant Fibrosis and Cirrhosis in Patients With Chronic Hepatitis C2003 · 4,426 citations
  2. 2Noninvasive diagnosis of the degree of hepatic fibrosis using ultrasonography in patients with chronic liver disease due to hepatitis C virus2001 · 57 citations
  3. 3A novel panel of blood markers to assess the degree of liver fibrosis†2005 · 560 citations