Key result
Catheter pressure at the earliest activation site is linked to a ~95% reduction in PVC burden.
Why the study?
Mechanical suppression of premature ventricular complexes during ablation procedures is not a well-known observation.
Does mechanical suppression of PVCs indicate a good site for successful ablation in patients undergoing ventricular arrhythmia ablation?
Observational (n=40)
No
Does mechanical suppression of PVCs indicate a good site for successful ablation in patients undergoing ventricular arrhythmia ablation?
Absolute Event Rate: 1.1% vs 24.04%
p-value: p=<0.05
Mechanical suppression of PVCs during catheter mapping is a reliable indicator of a successful ablation site, leading to a significant reduction in PVC burden.
Mechanical suppression may mark effective ablation targets; hypothesis-generating case report data leave open prospective validation.
INTRODUCTION: Mechanical suppression of premature ventricular complexes (PVCs) is not a well-known observation. We retrospectively reviewed this phenomenon in the Ventricular Arrhythmia (VA) ablation procedures performed at Richard L. Roudebush Veterans Health Administration (VHA) center. METHODS: Data from 40 consecutive patients who underwent VA ablation at VHA, Indianapolis, IN, with 44 VA was included in the study. Demographic and electrophysiological parameter data was collected. RESULTS: Overall the mean age of the population was 64 ± 11 years. The phenomenon of mechanical suppression was seen in 11 PVCs. The mean age was 59 ± 15 years in the group in which mechanical suppression was seen. Of the 11 cases, the site of earliest activation was seen in the coronary sinus in 8 and in the pulmonary artery in 3. In one case catheter ablation was not performed because of proximity to the left coronary artery system. However, sustained pressure at the site with earliest electrograms (-35 ms) and 95% pacematch resulted in long-term suppression of PVCs. In the cases in which mechanical suppression was seen, there was a statistically significant reduction in PVC burden compared to pre ablation PVC load (1.1% ± 1.50% (post ablation) versus 24.04% ± 13.07% (pre ablation) versus p < 0.05). In all the 11 cases the site of mechanical suppression was also the site with earliest electrograms. CONCLUSION: This case series illustrates phenomenon of mechanical suppression of PVCs as an indication for good site for successful ablation in unique veteran patient population.
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Jain et al. (2020) conducted an observational in Premature ventricular complexes (n=40). Mechanical suppression via catheter pressure vs. Pre-ablation baseline was evaluated on PVC burden (p=<0.05). Mechanical suppression of premature ventricular complexes by catheter pressure at the site of earliest activation significantly reduced PVC burden from 24.04% to 1.1%.
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