Why the study?
Does thyroid treatment improve right atrial monophasic action potentials and electrophysiological properties in patients with hypothyroidism?
Does thyroid treatment improve right atrial monophasic action potentials and electrophysiological properties in patients with hypothyroidism?
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Hypothyroidism causes reversible prolongation of right atrial monophasic action potentials and effective refractory periods, as well as AV conduction delays.
In 12 patients with manifest hypothyroidism right atrial monophasic action potentials showed a significant prolongation in comparison with data from normal or euthyroid patients. Atrial effective refractory periods were also significantly prolonged. After thyroid treatment the monophasic action potential duration and the effective refractory period of the right atrium were within normal ranges. In 6 hypothyroid patients studies of AV conduction with the aid of His bundle electrography and atrial pacing showed a supraHisian conduction delay which was manifest in one case and latent in another two. InfraHisian conduction delay was encountered in 2 cases.
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Gavrilescu et al. (1976) studied this question.
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