July 7, 2009Circulation
Trends in Cardiovascular Disease Risk Factors in Individuals With and Without Diabetes Mellitus in the Framingham Heart Study
Key result
From 1970 to 2005, individuals with diabetes experienced a greater decadal increase in BMI (+2.52 vs +0.39 kg/m2, P<0.001) and decrease in LDL-C (-15.5 vs -7.43 mg/dL) than those without diabetes.
Why the study?
Do trends in cardiovascular disease risk factors from 1970 to 2005 differ between individuals with and without type 2 diabetes mellitus?
Population
7,690 participants from the Framingham Heart Study, comprising 4,195 50-year-olds and 3,495 60-year-olds.
Comparison
Type 2 diabetes mellitus (exposure) vs No diabetes mellitus
Design
Cohort
Follow-up
1970 to 2005
Authors
Discussion
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Member takes
Implication
Diabetes patients' steeper BMI gains may offset LDL improvements and sustain CV risk; leaves open targeted obesity strategies in future cohorts.
Key Points
- The study aims to analyze changes in cardiovascular disease risk factor levels over time between individuals with and without diabetes mellitus.
- Included 4195 participants from the Framingham Heart Study, aged 50 and 60 years
- Measured cardiovascular disease risk factors and used linear regression models for analysis
- Compared changes over time between individuals with and without diabetes mellitus
- 50-year-olds with diabetes showed a 2.52 kg/m² increase in body mass index per decade (P<0.001)
- 50-year-olds with diabetes had a -15.5 mg/dL decrease in low-density lipoprotein cholesterol per decade (P=0.002)
- Systolic blood pressure decreased similarly for both diabetes and nondiabetes groups (P=0.97)
Study Design
Type
Cohort (n=7,690)
Structured PICO
Do trends in cardiovascular disease risk factors from 1970 to 2005 differ between individuals with and without type 2 diabetes mellitus?
P
Population
7,690 participants from the Framingham Heart Study, comprising 4,195 50-year-olds (3,990 without diabetes, 205 with diabetes) and 3,495 60-year-olds (3,178 without diabetes, 317 with diabetes).
I
Intervention
Type 2 diabetes mellitus (exposure)
C
Comparator
No diabetes mellitus
O
Outcome
Changes in cardiovascular disease risk factor levels (body mass index, low-density lipoprotein cholesterol, systolic blood pressure) from 1970 to 2005surrogate
Main Result
Absolute Event Rate: 2.52% vs 0.39%
p-value: p=<0.001
While individuals with diabetes experienced greater decreases in LDL cholesterol over time, they also had greater increases in BMI, indicating that risk factor improvements have been insufficient to overcome their elevated cardiovascular risk.
Cite This Study
Preis et al. (2009) conducted a cohort in Cardiovascular disease risk factors in diabetes mellitus (n=7,690). Diabetes mellitus vs. No diabetes mellitus was evaluated on Change in body mass index (kg/m2) per 10 years among 50-year-olds (p=<0.001). From 1970 to 2005, individuals with diabetes experienced a greater decadal increase in BMI (+2.52 vs +0.39 kg/m2, P<0.001) and decrease in LDL-C (-15.5 vs -7.43 mg/dL) than those without diabetes.