What question did this study set out to answer?

To evaluate the incidence and clinical burden of respiratory syncytial virus (RSV)–associated medically attended acute respiratory illness in adults with severe cardiopulmonary disease.

August 22, 2018Journal of Medical VirologyOpen Access

Respiratory syncytial virus–associated illness in adults with advanced chronic obstructive pulmonary disease and/or congestive heart failure

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Authors

AFAnn R. FalseyUniversity of Rochester EWEdward E. WalshUniversity of Rochester Medical Center MEMark T. EsserAstraZeneca (Netherlands)

Discussion

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Implication

Cohort study observes frequent but mild RSV-associated illness in adults with advanced COPD and heart failure, suggesting active vaccines may be preferable to monoclonal antibodies.

Key Points

To evaluate the incidence and clinical burden of respiratory syncytial virus (RSV)–associated medically attended acute respiratory illness in adults with severe cardiopulmonary disease.
Enrolled 445 participants aged ≥50 years with GOLD Class III/IV COPD and/or AHA Class III/IV congestive heart failure who had contact with children at least monthly.
Followed participants prospectively over 1.5 to 2.5 years to detect RSV-related medically attended acute respiratory illness (MARI), confirmed using PCR and serology.
Documented 99 total RSV infections by PCR or serology, yielding a cumulative incidence of 22.2%.
Identified protocol-defined RSV-associated MARI in 42 subjects (9.4%), representing an incidence rate of 4.68 per 100 patient-seasons.
Recorded an overall MARI incidence of 63.85 per 100 patient-seasons, and despite severe baseline disease, most RSV infections manifested as mild illness.

Cite This Study

Falsey et al. (2018) studied this question.

synapsesocial.com/papers/6a1586eaa2f71238514e81fd https://doi.org/10.1002/jmv.25285

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Implication

Cohort study observes frequent but mild RSV-associated illness in adults with advanced COPD and heart failure, suggesting active vaccines may be preferable to monoclonal antibodies.

Respiratory syncytial virus–associated illness in adults with advanced chronic obstructive pulmonary disease and/or congestive heart failure

Discussion

Member takes

Implication

Key Points

Cite This Study

Respiratory syncytial virus–associated illness in adults with advanced chronic obstructive pulmonary disease and/or congestive heart failure

Discussion

Member takes

Implication

Key Points

Cite This Study

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