Key result
Nesiritide infusion for 60 hours after acute MI significantly increased plasma BNP (276 vs 86 pg/l, P=0.001) and cGMP, with a neutral effect on renal function.
Why the study?
Does B-type natriuretic peptide infusion improve neurohormonal activation and renal function in patients with acute MI with delayed or failed reperfusion and moderate left ventricular dysfunction?
Population
28 patients with acute MI with delayed or failed reperfusion and moderate left ventricular dysfunction
Comparison
Infusion of B-type natriuretic peptide for 60… vs Placebo infusion for 60 hours after MI
Design
RCT, randomised, Double-blind
Follow-up
5 days
Authors
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Supports nesiritide for favorable neurohormonal modulation post-MI without renal harm; extends decompensated HF evidence to acute MI with reperfusion failure.
RCT (n=28)
Double-blind
Randomised
No
Does B-type natriuretic peptide infusion improve neurohormonal activation and renal function in patients with acute MI with delayed or failed reperfusion and moderate left ventricular dysfunction?
Absolute Event Rate: 276% vs 86%
p-value: p=0.001
Nesiritide infusion early after acute MI with delayed or failed reperfusion induces favorable neurohormonal changes without worsening renal function.
Hillock et al. (2007) conducted an RCT in Acute myocardial infarction (n=28). B-type natriuretic peptide (nesiritide) vs. Placebo was evaluated on Neurohormonal activation and renal function (p=0.001). Nesiritide infusion for 60 hours after acute MI significantly increased plasma BNP (276 vs 86 pg/l, P=0.001) and cGMP, with a neutral effect on renal function.
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