What does this research mean for the field?

In the human cardiac conduction system, vagal tone exerts a dominant depressant effect on sinuatrial node function and significantly increases atrioventricular node refractoriness, while autonomic effects on atrioventricular conduction are small and intraventricular conduction remains unaffected. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

August 1, 1980HeartOpen Access

Autonomic effects on the human cardiac conduction system. Evaluation by intracardiac electrocardiography and programmed stimulation techniques.

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Why the study?

Does cardiac autonomic block with intravenous atropine and propranolol alter electrophysiological variables of the cardiac conduction system in subjects undergoing right heart catheterisation?

Population

20 subjects, aged 30 to 82 years, undergoing right heart catheterisation

Comparison

Intravenous atropine 0.03 mg/kg and propranolol… vs Baseline determinations made before cardiac…

Design

Cohort

Authors

ATAndrew M. TonkinMonash University PTPilar TornosInterventional / Structural Cardiology WHWilliam HeddleFlinders University

Discussion

Member takes

Implication

Findings should not alter EP study protocols; extends knowledge of autonomic effects on nodal function.

Structured PICO

Does cardiac autonomic block with intravenous atropine and propranolol alter electrophysiological variables of the cardiac conduction system in subjects undergoing right heart catheterisation?

Population

20 subjects, aged 30 to 82 years, undergoing right heart catheterisation

Intervention

Intravenous atropine 0.03 mg/kg and propranolol 0.15 mg/kg to induce cardiac autonomic block

Comparator

Baseline determinations made before cardiac autonomic block

Outcome

Electrophysiological variables of normal function of the sinuatrial node, atrioventricular node, and intraventricular conduction system measured by intracardiac electrocardiography and programmed stimulationsurrogate

Intravenous atropine and propranolol demonstrate significant vagal and sympathetic influences on sinus node function and AV node refractoriness, with minimal effects on intraventricular conduction.

Limitations

Effects on refractory periods of the intraventricular conduction system could not be assessed because exact determinations were limited by refractoriness of the atrioventricular node

Cite This Study

Tonkin et al. (1980) studied this question.

synapsesocial.com/papers/6a1589cf5347fbb1739fef45 https://doi.org/10.1136/hrt.44.2.168

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Autonomic effects on the human cardiac conduction system. Evaluation by intracardiac electrocardiography and programmed stimulation techniques.

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

Autonomic effects on the human cardiac conduction system. Evaluation by intracardiac electrocardiography and programmed stimulation techniques.

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

Also Consider

Also Consider