Amlodipine once daily reduced systolic blood pressure on 24-h ambulatory monitoring to a significantly greater extent than nicardipine in elderly patients with isolated systolic hypertension.
RCT (n=133)
Double-blind
parallel-group
Yes
Does amlodipine once daily improve blood pressure reduction compared to nicardipine in elderly patients with isolated systolic hypertension?
Once-daily amlodipine provides superior 24-hour ambulatory systolic blood pressure reduction, particularly at night, compared to multiple daily doses of nicardipine in elderly patients with isolated systolic hypertension.
A 90-day, multicenter, randomized, double-blind, parallel-group study was conducted to compare the efficacy of amlodipine (once a day) with nicardipine (two to three times a day), in the treatment of isolated systolic hypertension (ISH) in the elderly. Patients (n = 133) aged > or = 60 years, with ISH were randomized to receive either amlodipine 5 mg/day, or nicardipine 60 mg/day (titrated if necessary to 10 mg/day and 100 mg/day, respectively) for 90 days. Efficacy was assessed by measuring office blood pressure (BP), and 24-h ambulatory blood pressure monitoring (ABPM). The two treatments substantially and comparably reduced office systolic blood pressure (SBP) and pulse pressure (PP), and also produced a slight decrease in diastolic blood pressure (DBP). Amlodipine reduced SBP, as assessed by ABPM, to a significantly greater extent than nicardipine. Both treatments were well-tolerated. The sustained effect of amlodipine, compared with nicardipine, was reflected in its significantly greater antihypertensive activity, particularly during the nocturnal period, as assessed by ABPM. The study demonstrates that once a day dose of amlodipine is an effective antihypertensive treatment for elderly ISH patients.
Mounier‐Véhier et al. (Sun,) conducted a rct in isolated systolic hypertension (ISH) (n=133). amlodipine vs. nicardipine 60 mg/day (titrated if necessary to 100 mg/day) was evaluated on office blood pressure (BP) and 24-h ambulatory blood pressure monitoring (ABPM). Amlodipine once daily reduced systolic blood pressure on 24-h ambulatory monitoring to a significantly greater extent than nicardipine in elderly patients with isolated systolic hypertension.