Fructose‐1,6‐bisphosphate reverses hypotensive effect caused by L‐kynurenine in Wistar male rats

Figures

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  FIGURE 1. Blood pressure and heart rate measures in response to KYN, KYN + FBP and FBP administrations. (a) Mean blood pressure (MBP), with a significant reduction in the KYN group compared to the naive and KYN + FBP groups. (b) Diastolic blood pressure (DBP), with a significant reduction in the KYN group compared to the other groups. (c) Systolic blood pressure (SBP), with no significant difference when comparing groups. (d) Heart rate variability (HRV), with significantly greater variation in the KYN group compared to the naïve and KYN + FBP groups. Naive and KYN group (n = 7); KYN + FBP (n = 6). Data are presented as mean ± standard deviation.

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  FIGURE 2. Docking validation structures. KCNQ4 voltage‐gated potassium channel crystallographic structure is represented as cartoon. (a) The crystalographic structure of retigabine (green) and FBP docking pose (cyan), (b) The crystalographic structure of retigabine (green) and KYN docking pose (pink), and (c) The crystalographic structure of retigabine (green) and retigabine docking pose (yellow) are represented in stick model. Elaborated using Pymol 2.3.3.

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  FIGURE 3. Two‐dimensional diagrams of complexes of interaction with KCNQ4 voltage‐gated potassium channel. Directed bonds between protein (channel) and ligand are drawn as dashed lines and the interacting protein residues and the ligand are visualized as structure diagrams. Hydrophobic contacts are represented more indirectly through spline sections highlighting the hydrophobic parts of the ligand and the label of the contacting residue. (a) KCNQ4 voltage‐gated potassium channel in liganding interaction with retigabine. (b) KCNQ4 voltage‐gated potassium channel in liganding interaction with FBP. (c) KCNQ4 voltage‐gated potassium channel in liganding interaction with KYN. Figure generated using PoseView.