Design
Review
Key result
CaMKII regulates fundamental proteins involved in cardiac excitation-contraction coupling, and its dysregulation constitutes a central mechanism in cardiac diseases like ischemia/reperfusion injury, arrhythmias, and hypertrophy.
Authors
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CaMKII dysregulation merits mechanistic study in cardiac disease; extends conceptual framework but leaves open targeted clinical translation.
This review provides a conceptual framework for understanding the central role of the CaMKII cascade in cardiac physiology and various cardiac pathologies.
Mattiazzi et al. (2015) conducted a review in Cardiac physiology and pathology. CaMKII regulates fundamental proteins involved in cardiac excitation-contraction coupling, and its dysregulation constitutes a central mechanism in cardiac diseases like ischemia/reperfusion injury, arrhythmias, and hypertrophy.
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