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January 1, 2014Frontiers in PharmacologyOpen Access

CaMKIIdelta subtypes: localization and function

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Key result

CaMKIIδ subtypes δB and δC exhibit distinct localizations and functions in the heart, with δB primarily regulating gene transcription and δC modulating cytosolic calcium handling and arrhythmogenesis.

Design

Review

Authors

CGCharles B.B. GrayUniversity of California, San DiegoJBJoan Heller BrownUniversity of North Carolina at Chapel Hill

Discussion

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Implication

Further delineates CaMKIIδ subtype roles in cardiac disease; leaves open isoform-selective targeting for future therapies.

Key Points

  • This review aims to explore the localization and functional significance of CaMKIIdelta subtypes in cardiac physiology, particularly in the context of arrhythmias and contractile dysfunction.
  • Reviewed known subtypes of CaMKIIdelta and their expression in cardiac tissue.
  • Analyzed the effects of CaMKIIdelta subtypes on gene transcription and calcium handling.
  • Examined the role of CaMKIIdelta in arrhythmias and contractile dysfunction.
  • CaMKIIdeltaB is the predominant isoform in the heart and has a nuclear localization sequence important for its function.
  • Both δB and δC subtypes play critical roles in calcium handling and contractile regulation.
  • Alterations in these subtypes are implicated in the development of cardiac arrhythmias.

PICO

P
Population
Cardiac physiology and pathophysiology
I
Intervention / Comparator
CaMKIIδ subtypes (δB and δC)

This review highlights the distinct subcellular localizations and pathophysiological roles of CaMKIIδ splice variants in the heart, offering insights into mechanisms of heart failure and arrhythmias.

Limitations

  • It remains to be determined whether the distinct functions of δB and δC observed in vitro occur in vivo under physiological or pathophysiological conditions.

Cite This Study

Gray et al. (2014) conducted a review in Cardiac physiology and pathophysiology. CaMKIIδ subtypes (δB and δC) was evaluated. CaMKIIδ subtypes δB and δC exhibit distinct localizations and functions in the heart, with δB primarily regulating gene transcription and δC modulating cytosolic calcium handling and arrhythmogenesis.

synapsesocial.com/papers/6a6c12ef8630bd5253cb206dhttps://doi.org/10.3389/fphar.2014.00015
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Cardioprotection by CaMKII-δB Is Mediated by Phosphorylation of Heat Shock Factor 1 and Subsequent Expression of Inducible Heat Shock Protein 702009 · 129 citations
  2. 2The Nuclear δB Isoform of Ca2+/Calmodulin-dependent Protein Kinase II Regulates Atrial Natriuretic Factor Gene Expression in Ventricular Myocytes1997 · 212 citations
  3. 3CaMKII Negatively Regulates Calcineurin–NFAT Signaling in Cardiac Myocytes2009 · 151 citations
  4. 4Ca 2+ /Calmodulin-Dependent Kinase IIδ Causes Heart Failure by Accumulation of p53 in Dilated Cardiomyopathy2010 · 95 citations
  5. 5Calmodulin Kinase II and Arrhythmias in a Mouse Model of Cardiac Hypertrophy2002 · 269 citations