Population
Cultured neonatal rat ventricular myocytes and adult feline ventricular myocytes
Comparison
Constitutively active or dominant negative… vs Control
Design
Preclinical
Authors
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May modulate hypertrophic signaling via NFAT in myocytes; leaves open clinical translation from animal models.
Cytoplasmic CaMKII negatively regulates calcineurin-NFAT signaling in cardiac myocytes by directly phosphorylating and inhibiting calcineurin, which may impact hypertrophic and survival signaling.
MacDonnell et al. (2009) studied this question.
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