Why the study?
Does TNF-α induce myocardial hypertrophy via Ca2+/CaMKII- and CaN-dependent signaling pathways in cultured neonatal rat cardiomyocytes?
Population
Cultured cardiomyocytes of neonatal Wistar rats (1-2 days old)
Comparison
TNF-α with or without antagonists vs Control (untreated cardiomyocytes)
Design
Preclinical
Follow-up
up to 72 hours
Authors
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Findings in neonatal rat cells require human validation; leaves open TNF-α pathway targeting in clinical hypertrophy.
Does TNF-α induce myocardial hypertrophy via Ca2+/CaMKII- and CaN-dependent signaling pathways in cultured neonatal rat cardiomyocytes?
TNF-α induces myocardial hypertrophy in neonatal rat cardiomyocytes through Ca2+/CaMKII- and calcineurin-dependent signaling pathways.
Wang et al. (2012) studied this question.
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