Key result
Transverse aortic constriction induced a 33% increase in total CaMK activity at 7 days, selectively up-regulating CaMKII isoforms in the ventricles.
Population
Mice subjected to transverse aortic constriction to induce cardiac hypertrophy
Design
Preclinical
Follow-up
7 days
Authors
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Suggests CaMKII as hypertrophy target; leaves open translation to human heart failure therapies.
CaMKII is selectively up-regulated in response to pressure overload and is the likely mediator of Ca2+-dependent signaling in cardiac hypertrophy.
Colomer et al. (2003) studied Cardiac hypertrophy. Transverse aortic constriction (TAC) was evaluated on Total CaMK activity and levels of CaMK isoforms. Transverse aortic constriction induced a 33% increase in total CaMK activity at 7 days, selectively up-regulating CaMKII isoforms in the ventricles.
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