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March 20, 2010AJP Heart and Circulatory PhysiologyOpen Access

Isoform- and tissue-specific regulation of the Ca2+-sensitive transcription factor NFAT in cardiac myocytes and heart failure

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Population

Adult cat and rabbit cardiac myocytes, including ventricular myocytes from heart failure rabbits.

Comparison

Stimulation with angiotensin II, endothelin-1… vs Control myocytes / basal conditions.

Design

Preclinical

Authors

ARAndreas RinneNKNidhi KapurJMJeffery D. Molkentin

Discussion

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Overview

Isoform-specific NFAT regulation in HF models may guide targeted therapies; leaves open whether NFATc3 modulation alters human outcomes.

Structured PICO

P
Population
Adult cat and rabbit cardiac myocytes (atrial and ventricular), including ventricular myocytes from heart failure rabbits.
I
Intervention
Stimulation with angiotensin II, endothelin-1, phenylephrine, or calcium overload; inhibition of calcineurin or nuclear export (leptomycin B).
C
Comparator
Control myocytes / basal conditions.
O
Outcome
Basal localization, import, and export of NFATc1 and NFATc3.surrogate

NFAT activation in adult cardiomyocytes is isoform- and tissue-specific, and its increased nuclear localization in heart failure may be secondary to calcium overload.

Cite This Study

Rinne et al. (2010) studied this question.

synapsesocial.com/papers/6a6f6370439bab0cabc2c623https://doi.org/10.1152/ajpheart.01072.2009
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Also Consider

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