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November 13, 2009Circulation ResearchOpen Access

Cardioprotection by CaMKII-δB Is Mediated by Phosphorylation of Heat Shock Factor 1 and Subsequent Expression of Inducible Heat Shock Protein 70

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Population

Cultured neonatal rat cardiomyocytes and in vivo rat myocardial ischemia/reperfusion (IR) model

Comparison

Overexpression of CaMKII-deltaB vs Overexpression of CaMKII-deltaC or control

Design

Preclinical

Authors

WPWei PengGuangxi UniversityYZYan ZhangBinzhou UniversityMZMing ZhengWenzhou Medical University

Discussion

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Implication

Isoform-selective CaMKII modulation may reduce cardiomyocyte apoptosis in ischemic settings; leaves open in vivo translation and clinical relevance.

Structured PICO

P
Population
Cultured neonatal rat cardiomyocytes and in vivo rat myocardial ischemia/reperfusion (IR) model
I
Intervention
Overexpression of CaMKII-deltaB
C
Comparator
Overexpression of CaMKII-deltaC or control
O
Outcome
Cardiomyocyte apoptosissurrogate

CaMKII-deltaB acts as a potent suppressor of cardiomyocyte apoptosis via phosphorylation of HSF1 and induction of iHSP70, identifying it as a potential therapeutic target for ischemic heart disease.

Cite This Study

Peng et al. (2009) studied this question.

synapsesocial.com/papers/6a7c17d7050daa66a5df7b60https://doi.org/10.1161/circresaha.109.210914
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Apoptosis in Myocytes in End-Stage Heart Failure1996 · 1,445 citations
  2. 2The Cardiac-specific Nuclear δB Isoform of Ca2+/Calmodulin-dependent Protein Kinase II Induces Hypertrophy and Dilated Cardiomyopathy Associated with Increased Protein Phosphatase 2A Activity2002 · 244 citations
  3. 3The Role of Calmodulin Kinase II in Myocardial Physiology and Disease2008 · 141 citations
  4. 4?-Ca2+/calmodulin-dependent protein kinase II expression pattern in adult mouse heart and cardiogenic differentiation of embryonic stem cells2000 · 21 citations
  5. 5Linkage of β1-adrenergic stimulation to apoptotic heart cell death through protein kinase A–independent activation of Ca2+/calmodulin kinase II2003 · 379 citations