Key result
MASLD is linked to increased arterial stiffness compared to healthy controls.
Why the study?
The study was conducted to investigate the association of metabolic dysfunction-associated steatotic liver disease with arterial stiffness and shed light on potential cardiometabolic co-factors.
Is metabolic dysfunction-associated steatotic liver disease (MASLD) associated with increased arterial stiffness in adults compared to healthy individuals?
Meta-Analysis
Is metabolic dysfunction-associated steatotic liver disease (MASLD) associated with increased arterial stiffness in adults compared to healthy individuals?
p-value: p=0.0195
MASLD is associated with increased arterial stiffness independent of common cardiometabolic risk factors, highlighting a potential link between steatotic liver disease and vascular aging.
INTRODUCTION: The purpose of this systematic review and meta-analysis is to investigate the association of metabolic dysfunction-associated steatotic liver disease (MASLD) with arterial stiffness and enlighten on potential cardiometabolic co-factors. METHODS: A literature search in PubMed/Medline, Embase, Scopus, and Web of Science databases was conducted. All the observational studies comparing arterial stiffness indices between adults with Non-alcoholic Fatty Liver Disease (NAFLD), Metabolic Dysfunction Associated-Fatty Liver Disease (MAFLD), or MASLD and apparently healthy individuals with normal liver function were included. Pulse wave velocity (PWV) and augmentation index (AIx) were mainly used as arterial stiffness indices. RESULTS: = 0.0195) compared with controls. CONCLUSIONS: MASLD is correlated with increased arterial stiffness. This relation is unaffected by common cardiometabolic risk factors. REGISTRATION: PROSPERO (ID: CRD42023468258).
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Giannakodimos et al. (2025) conducted a meta-analysis in Metabolic dysfunction-associated steatotic liver disease (MASLD). Metabolic dysfunction-associated steatotic liver disease (MASLD) vs. Apparently healthy individuals with normal liver function was evaluated on Arterial stiffness indices (Pulse wave velocity and augmentation index) (p=0.0195). Metabolic dysfunction-associated steatotic liver disease (MASLD) is correlated with increased arterial stiffness compared with healthy controls (P=0.0195).
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