Key result
The Lee Cardiac Risk Index and ACE-27 scores, combined with age >70 years, effectively predicted major cardiovascular complications after extensive HNSCC surgery (AUC 0.84; p<0.01).
Why the study?
Can the Lee Cardiac Risk Index (LCRI) and Adult Comorbidity Evaluation (ACE-27) scores predict major cardiovascular complications in patients undergoing extensive head and neck surgery for HNSCC?
Cohort (n=135)
Can the Lee Cardiac Risk Index (LCRI) and Adult Comorbidity Evaluation (ACE-27) scores predict major cardiovascular complications in patients undergoing extensive head and neck surgery for HNSCC?
Effect estimate: AUC 0.84
p-value: p=<0.01
The Lee Cardiac Risk Index and ACE-27 scores, especially when combined with age >70 years, are effective tools for predicting major cardiovascular complications in patients undergoing extensive head and neck cancer surgery.
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May support preoperative risk stratification in extensive HNSCC surgery; hypothesis-generating and requires prospective validation.
Datema et al. (2010) conducted a cohort in Head and neck squamous cell carcinoma (HNSCC) (n=135). Lee Cardiac Risk Index (LCRI) and Adult Comorbidity Evaluation (ACE-27) scores vs. American Society of Anesthesiologists' (ASA) classification was evaluated on Major cardiovascular complications (cardiac death, nonfatal myocardial infarction, heart failure, and cardiac arrhythmias) (AUC 0.84, p=<0.01). The Lee Cardiac Risk Index and ACE-27 scores, combined with age >70 years, effectively predicted major cardiovascular complications after extensive HNSCC surgery (AUC 0.84; p<0.01).
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