What question did this study set out to answer?

To review the mechanisms through which injury-induced bioelectric fields initiate, coordinate, and guide individual and collective epithelial cell migration during wound healing.

August 30, 2022Cold Spring Harbor Perspectives in BiologyOpen Access

Bioelectric Signaling: Role of Bioelectricity in Directional Cell Migration in Wound Healing

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Authors

MZMin ZhaoGuangzhou University of Chinese Medicine MRMarco RolandiUniversity of California, Santa Cruz RIR. Rivkah IsseroffVA Northern California Health Care System

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Implication

Review demonstrates how endogenous electric fields guide directional epithelial cell migration in injured tissue, indicating the therapeutic promise of bioelectric signaling in wound healing.

Key Points

To review the mechanisms through which injury-induced bioelectric fields initiate, coordinate, and guide individual and collective epithelial cell migration during wound healing.
Synthesized literature on the generation and maintenance of endogenous electric fields across damaged epithelial barriers.
Evaluated experimental evidence detailing electrotactic responses and collective directional migration in keratinocytes and corneal epithelial sheets.
Skin wounding breaks the epithelial barrier, establishing endogenous electric fields directed toward a cathodal pole at the wound center via ion transport.
Applied and naturally occurring electric fields drive both isolated cell migration and the coordinated directional movement of intact epithelial sheets through specialized collective mechanisms.

Cite This Study

Zhao et al. (2022) studied this question.

synapsesocial.com/papers/6a158beecb0379474a8252db https://doi.org/10.1101/cshperspect.a041236

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Implication

Review demonstrates how endogenous electric fields guide directional epithelial cell migration in injured tissue, indicating the therapeutic promise of bioelectric signaling in wound healing.

Bioelectric Signaling: Role of Bioelectricity in Directional Cell Migration in Wound Healing

Discussion

Member takes

Implication

Key Points

Cite This Study

Bioelectric Signaling: Role of Bioelectricity in Directional Cell Migration in Wound Healing

Discussion

Member takes

Implication

Key Points

Cite This Study

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