What does this research mean for the field?

M mode echocardiography indices of diastolic filling are consistently abnormal in patients with left ventricular hypertrophy compared to controls, whereas Doppler indices vary widely, demonstrating that the two methods measure different, complementary aspects of left ventricular diastolic function. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To evaluate potential discrepancies between digitized M-mode and Doppler echocardiography when measuring early left ventricular diastolic filling.

April 1, 1991HeartOpen Access

Diastolic disease in left ventricular hypertrophy: comparison of M mode and Doppler echocardiography for the assessment of rapid ventricular filling.

Q: What is the clinical evidence from this study?

Study design: Observational. Population: Left ventricular hypertrophy due to aortic stenosis (n=73). Intervention: M mode echocardiography vs. Doppler echocardiography. Primary outcome: Filling velocities on Doppler and rates of wall thinning and dimension increase on M mode.

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Key result

M mode echocardiography indices of diastolic filling were consistently abnormal in patients with left ventricular hypertrophy compared to controls, whereas Doppler indices varied widely.

Why the study?

Does M mode echocardiography improve the assessment of early diastolic filling compared to Doppler echocardiography in patients with left ventricular hypertrophy?

Key Points

To evaluate potential discrepancies between digitized M-mode and Doppler echocardiography when measuring early left ventricular diastolic filling.
Assessed 47 patients with left ventricular hypertrophy secondary to aortic stenosis alongside 26 healthy age-matched control subjects.
Evaluated early diastolic filling parameters using digitized M-mode echocardiography, Doppler ultrasound, apexcardiography, phonocardiography, and cardiac catheterization.
Digitized M-mode indices were consistently reduced in patients compared to controls, including peak wall thinning rate (6.4 [3.0] vs 10.0 [3.0] cm/s) and peak rate of dimension increase (9.3 [3.3] vs 16 [4.5] cm/s).
Doppler A/E ratio and peak E wave velocity varied widely among hypertrophy patients due to heightened sensitivity to isovolumic relaxation abnormalities, and varied with age in parallel to healthy controls.
Neither Doppler filling parameters nor M-mode indices correlated significantly with left ventricular end-diastolic pressure or peak aortic pressure gradients.

Study Design

Type

Observational (n=73)

Multicenter

Structured PICO

Does M mode echocardiography improve the assessment of early diastolic filling compared to Doppler echocardiography in patients with left ventricular hypertrophy?

Population

47 patients with left ventricular hypertrophy due to aortic stenosis and 26 healthy controls with a similar age range

Intervention

M mode echocardiography (digitised)

Comparator

Doppler echocardiography

Outcome

Early diastolic filling assessment (filling velocities on Doppler and rates of wall thinning and dimension increase on M mode)surrogate

M mode and Doppler echocardiography measure different aspects of left ventricular diastolic function and should be considered complementary rather than interchangeable in patients with left ventricular hypertrophy.

Discussion

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Implication

Supports complementary use of M-mode and Doppler in LVH diastolic assessment; hypothesis-generating for modality-specific insights.

Cite This Study

Lee et al. (1991) conducted an observational in Left ventricular hypertrophy due to aortic stenosis (n=73). M mode echocardiography vs. Doppler echocardiography was evaluated on Filling velocities on Doppler and rates of wall thinning and dimension increase on M mode. M mode echocardiography indices of diastolic filling were consistently abnormal in patients with left ventricular hypertrophy compared to controls, whereas Doppler indices varied widely.

synapsesocial.com/papers/6a158cac79ff98d0de4ecc39 https://doi.org/10.1136/hrt.65.4.194

Topics

Echocardiography

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Diastolic disease in left ventricular hypertrophy: comparison of M mode and Doppler echocardiography for the assessment of rapid ventricular filling.

Key Points

Study Design

Structured PICO

Discussion

Implication

Cite This Study

Topics

Diastolic disease in left ventricular hypertrophy: comparison of M mode and Doppler echocardiography for the assessment of rapid ventricular filling.

Key Points

Study Design

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Topics

Also Consider