Key result
Plasma DNA concentration on ICU admission was an independent predictor of mortality (OR 1.002) and was significantly higher in patients who died in the ICU (321 ng/ml) compared to survivors (71 ng/ml).
Why the study?
Does plasma DNA concentration on admission predict mortality and sepsis in critically ill patients?
Population
52 consecutive critically ill patients admitted to a general intensive care unit (ICU).
Comparison
Measurement of plasma DNA concentration on… vs Healthy controls, or patients with lower plasma…
Design
Cohort
Follow-up
up to 3 months
Authors
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May aid early risk stratification in ICU patients; hypothesis-generating for sepsis prediction pending validation.
Observational (n=52)
No
Does plasma DNA concentration on admission predict mortality and sepsis in critically ill patients?
Effect estimate: OR 1.002 (95% CI 1.0-1.004)
p-value: p=0.05
Elevated plasma DNA concentration on ICU admission serves as an independent predictor of mortality and the development of severe sepsis.
Rhodes et al. (2006) conducted an observational in Critically ill patients (n=52). Plasma DNA concentration was evaluated on Mortality (OR 1.002, 95% CI 1.0-1.004, p=0.05). Plasma DNA concentration on ICU admission was an independent predictor of mortality (OR 1.002) and was significantly higher in patients who died in the ICU (321 ng/ml) compared to survivors (71 ng/ml).
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