Key result
Epicardial repolarization dispersion with delayed potentials linked to spontaneous VF in Brugada syndrome.
Why the study?
There have been no reports recording epicardial electrograms at the onset of spontaneous ventricular fibrillation in patients with Brugada syndrome.
Can epicardial electrogram mapping identify phase 2 reentry and dispersion of repolarization at the onset of spontaneous VF in Brugada syndrome?
Case Report (n=1)
Can epicardial electrogram mapping identify phase 2 reentry and dispersion of repolarization at the onset of spontaneous VF in Brugada syndrome?
Epicardial unipolar mapping can identify dispersion of repolarization and phase 2 reentry in Brugada syndrome, potentially guiding accurate ablation of arrhythmia substrates.
Hypothesis-generating for epicardial mapping to identify VF substrates in Brugada syndrome; leaves open prospective validation for ablation guidance.
To date, there have been no reports of recording epicardial electrograms at the onset of spontaneous ventricular fibrillation (VF) in patients with Brugada syndrome (BrS). In the case of BrS, unipolar and bipolar electrogram recording on the right ventricular epicardium revealed that dispersion of repolarization with delayed potential was associated with spontaneous occurrence of VF. Phase 2 reentry associated with shortening and dispersion of action potential could have been recorded for the first time in BrS. Epicardial unipolar mapping can guide accurate and appropriate ablation for the elimination of arrhythmia substrate in J wave syndrome.
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Nagase et al. (2024) conducted a case report in Brugada syndrome (n=1). Epicardial unipolar and bipolar electrogram recording was evaluated on Spontaneous occurrence of ventricular fibrillation. Epicardial electrogram recording in Brugada syndrome revealed that dispersion of repolarization with delayed potential was associated with the spontaneous occurrence of ventricular fibrillation.
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