Patients with mitral valve prolapse and mitral annular disjunction had significantly higher myocardial extracellular volume compared to controls (30% vs 24%, p<0.001), indicating increased interstitial fibrosis.
Observational (n=54)
No
Does myocardial extracellular volume (ECVsyn) by T1 mapping correlate with mitral annular disjunction severity and identify arrhythmic risk in patients with mitral valve prolapse?
Myocardial extracellular volume (ECVsyn) by T1 mapping is increased in patients with mitral valve prolapse and mitral annular disjunction, correlating with disjunction length and identifying patients at high risk for out-of-hospital cardiac arrest even without late gadolinium enhancement.
Absolute Event Rate: 30% vs 24%
p-value: p=<0.001
OBJECTIVES: We aimed to evaluate the relationship between mitral annular disjunction (MAD) severity and myocardial interstitial fibrosis at the left ventricular (LV) base in patients with mitral valve prolapse (MVP), and to assess the association between severity of interstitial fibrosis and the occurrence of ventricular arrhythmic events. BACKGROUND: In MVP, MAD has been associated with myocardial replacement fibrosis and arrhythmia, but the importance of interstitial fibrosis remains unknown. METHODS: In this retrospective study, 30 patients with MVP and MAD (MVP-MAD) underwent cardiovascular magnetic resonance (CMR) with assessment of MAD length, late gadolinium enhancement (LGE), and basal segments myocardial extracellular volume (ECVsyn). The control group included 14 patients with mitral regurgitation (MR) but no MAD (MR-NoMAD) and 10 patients with normal CMR (NoMR-NoMAD). Fifteen MVP-MAD patients underwent 24 h-Holter monitoring. RESULTS: LGE was observed in 47% of MVP-MAD patients and was absent in all controls. ECVsyn was higher in MVP-MAD (30 ± 3% vs 24 ± 3% MR-NoMAD, p < 0.001 and vs 24 ± 2% NoMR-NoMAD, p < 0.001), even in MVP-MAD patients without LGE (29 ± 3% vs 24 ± 3%, p < 0.001 and vs 24 ± 2%, p < 0.001, respectively). MAD length correlated with ECVsyn (rho = 0.61, p < 0.001), but not with LGE extent. Four patients had history of out-of-hospital cardiac arrest; LGE and ECVsyn were equally performant to identify those high-risk patients, area under the receiver operating characteristic (ROC) curve 0.81 vs 0.83, p = 0.84). Among patients with Holter, 87% had complex ventricular arrhythmia. ECVsyn was above the cut-off value in all while only 53% had LGE. CONCLUSION: Increase in ECVsyn, a marker of interstitial fibrosis, occurs in MVP-MAD even in the absence of LGE, and was correlated with MAD length and increased risk of out-of-hospital cardiac arrest. ECV should be includedin the CMR examination of MVP patients in an effort to better assess fibrous remodelling as it may provide additional value beyond the assessment of LGE in the arrhythmic risk stratification.
Pavon et al. (Mon,) conducted a observational in Mitral valve prolapse (MVP) with mitral annular disjunction (MAD) (n=54). Mitral valve prolapse with mitral annular disjunction (MVP-MAD) vs. Mitral regurgitation without MAD (MR-NoMAD) and normal CMR (NoMR-NoMAD) was evaluated on Basal segments myocardial extracellular volume (ECVsyn) (p=<0.001). Patients with mitral valve prolapse and mitral annular disjunction had significantly higher myocardial extracellular volume compared to controls (30% vs 24%, p<0.001), indicating increased interstitial fibrosis.