August 7, 2017Scientific ReportsOpen Access

Virtual cardiac monolayers for electrical wave propagation

Q: What is the clinical evidence from this study?

Study design: Other. Population: Cardiac tissue formation and electrical wave propagation. Intervention: Glazier-Graner-Hogeweg (GGH) mathematical model vs. In vitro experimental data. Primary outcome: Cell shape characteristics and wave propagation anisotropy.

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Key result

A mathematical model based on the Glazier-Graner-Hogeweg approach successfully reproduced the morphological properties and electrical wave propagation anisotropy of cardiac tissue observed in vitro.

Population

Neonatal rat ventricular cells cultured in vitro under four conditions: isolated cells on uniform substrate…

Comparison

Mathematical modeling of cardiac tissue… vs In vitro experimental optical mapping of…

Design

Preclinical

Authors

NKNina KudryashovaLeiden University Medical Center VTValeriya TsvelayaMinistry of Health of the Russian Federation KAKonstantin AgladzeMinistry of Health of the Russian Federation

Discussion

Member takes

Implication

Offers a computational tool for arrhythmogenic substrate modeling; leaves open validation and clinical translation.

Structured PICO

Population

Neonatal rat ventricular cells (cardiomyocytes and fibroblasts) cultured in vitro under four conditions: isolated cells on uniform substrate, isolated cells on polymer nanofibres, isotropic monolayers, and monolayers on nanofibres (n=601 cells).

Intervention

Mathematical modeling of cardiac tissue formation using the Glazier-Graner-Hogeweg (GGH) model coupled with the Korhonen-Majumder electrophysiological model.

Comparator

In vitro experimental optical mapping of neonatal rat ventricular cell cultures.

Outcome

Morphological and physiological properties of cardiac tissue, including cell shape, wave propagation, anisotropy ratio, and wavefront complexity.surrogate

A novel mathematical model based on the Glazier-Graner-Hogeweg approach successfully reproduces the morphological and physiological properties of cardiac tissue, providing a computational tool to study arrhythmogenic substrates.

Limitations

The current version of the model exhibits low motility of the cells, limiting the study of cell migration and sorting.
The model reproduces only the average cell and does not account for the wide parameter distribution and variability observed in real cells.
The model is currently two-dimensional and needs to be extended to a third dimension to accurately describe in vivo tissues.
Substantial difference in the variability of shape parameters between experiments and simulations due to the assumed homogeneity of the cell population in the model.

Cite This Study

Kudryashova et al. (2017) studied Cardiac tissue formation and electrical wave propagation. Glazier-Graner-Hogeweg (GGH) mathematical model vs. In vitro experimental data was evaluated on Cell shape characteristics and wave propagation anisotropy. A mathematical model based on the Glazier-Graner-Hogeweg approach successfully reproduced the morphological properties and electrical wave propagation anisotropy of cardiac tissue observed in vitro.

synapsesocial.com/papers/6a15922d37103a43379fed46 https://doi.org/10.1038/s41598-017-07653-3

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Virtual cardiac monolayers for electrical wave propagation

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

Virtual cardiac monolayers for electrical wave propagation

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

Also Consider

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