Key result
Diamond-tip catheter ablation at 50 W yields ~67% larger lesions than lower or shorter settings.
Why the study?
New catheter technology has integrated more accurate tissue temperature sensing enabling temperature-controlled irrigated ablation, but in vivo ablation parameters and lesion formation characteristics in ventricular myocardium required investigation.
Does temperature-controlled radiofrequency ablation with a diamond-tip catheter create effective and safe lesions in normal and infarcted ventricular myocardium in a preclinical model?
Comparison
Various temperature-controlled radiofrequency ablation settings in normal vs infarcted myocardium
Design
Preclinical in vivo animal study
Follow-up
5 weeks after ablation in phases II/III
Authors
Loading...
Supports optimized lesion creation in preclinical ventricular models; human trials required before clinical translation.
Does temperature-controlled radiofrequency ablation with a diamond-tip catheter create effective and safe lesions in normal and infarcted ventricular myocardium in a preclinical model?
Absolute Event Rate: 569.2% vs 340.4%
p-value: p=<0.05
A novel temperature-controlled diamond-tip radiofrequency catheter safely created large, deep lesions in both normal and infarcted canine ventricular myocardium without steam pops.
Hirao et al. (2025) studied Ventricular ablation (normal and infarcted myocardium) (n=20). Temperature-controlled radiofrequency ablation with a diamond-tip catheter vs. Other ablation settings (e.g., 50 W/60 °C/30 s and 50 W/50 °C/60 s) was evaluated on Lesion volume (mm3) (p=<0.05). Ablation with a diamond-tip temperature-controlled catheter at 50 W, 60 °C, and 60 s produced significantly larger lesions (mean 569.2 mm3) than shorter or lower-temperature settings (P<0.05).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: