Key result
Radiofrequency gastric ablation safely induces sustained localized conduction block in 100% of pigs without perforation.
Why the study?
Previous studies of gastric ablation to modulate electrical activation were limited to the acute intraoperative setting, leaving safety and persistence after healing unstudied.
Does radiofrequency gastric ablation safely create persistent localized bioelectrical conduction blocks in a porcine recovery model?
Does radiofrequency gastric ablation safely create persistent localized bioelectrical conduction blocks in a porcine recovery model?
Absolute Event Rate: 100% vs 0%
Radiofrequency gastric ablation safely creates localized bioelectrical conduction blocks that persist after 2 weeks of healing in a porcine model, demonstrating feasibility for modulating gastric electrical activation.
Establishes proof-of-concept for gastric neuromodulation in pigs; leaves open translation to human motility disorders.
Ablation has recently emerged as a tool for modulating gastric electrical activation and may hold interventional potential for disorders of gastric function. However, previous studies have been limited to the acute intraoperative setting. This study now presents the safety of gastric ablation after postsurgical recovery and healing. Localized electrical conduction blocks created by ablation remained after 2 wk of healing, and no perforation or other complications were observed over the postsurgical period.
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Aghababaie et al. (2022) studied Healthy (evaluating gastric ablation) (n=6). Radiofrequency (RF) gastric ablation vs. Sham-ablation was evaluated on Sustained localized conduction block at 2 weeks. Radiofrequency gastric ablation safely induced a sustained localized conduction block in 100% of treated pigs after 2 weeks of healing, compared to 0% in sham controls, without causing perforation.
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