Key result
Female ALL survivors treated with low cumulative anthracycline doses (mean 228.2 mg/m2) showed reduced left ventricular mass and wall thickness compared to matched healthy controls.
Why the study?
Do low cumulative anthracycline doses induce echocardiographic abnormalities in long-term survivors of pediatric acute lymphoblastic leukemia?
Population
62 long-term survivors of pediatric acute lymphoblastic leukemia without overt or sub-clinical signs or…
Comparison
Low cumulative anthracycline doses vs Age, gender, and body surface area matched group…
Design
Case-control
Follow-up
12.6 ± 4.3 years after stopping therapy
Authors
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May support targeted echo surveillance in female survivors; leaves open prospective causality and dose thresholds.
Case-Control (n=62)
Do low cumulative anthracycline doses induce echocardiographic abnormalities in long-term survivors of pediatric acute lymphoblastic leukemia?
Low cumulative doses of anthracyclines in pediatric ALL survivors are associated with reduced LV mass and wall thickness specifically in females, suggesting a need for long-term echocardiographic follow-up in this subgroup.
Amigoni et al. (2010) conducted a case-control in Acute lymphoblastic leukemia (ALL) long-term survivors (n=62). Low cumulative anthracycline doses vs. Age, gender and BSA matched healthy subjects was evaluated on Left ventricular (LV) structure and function. Female ALL survivors treated with low cumulative anthracycline doses (mean 228.2 mg/m2) showed reduced left ventricular mass and wall thickness compared to matched healthy controls.
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