Key result
Selective changes in Angiotensin II receptor subtypes occur in cardiovascular diseases, thyroid dysfunction, diabetes, and hypertension, suggesting potential for subtype-selective targeted therapies.
Population
Models of cardiovascular disease and human heart tissue
Design
Review
Authors
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May support subtype-selective angiotensin therapies; leaves open clinical efficacy pending prospective trials.
Selective changes in angiotensin II receptor subtypes across different cardiovascular disease models highlight the potential for targeted therapies using subtype-selective agonists and antagonists.
Brown et al. (1994) conducted a review in Cardiovascular diseases, thyroid dysfunction, diabetes, hypertension. Selective changes in Angiotensin II receptor subtypes occur in cardiovascular diseases, thyroid dysfunction, diabetes, and hypertension, suggesting potential for subtype-selective targeted therapies.
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