Key result
Recent advancements in imaging, electrophysiological mapping, and ablative therapies, including SBRT and AI, have improved the management of ventricular arrhythmias in non-ischemic cardiomyopathy.
Why the study?
Ventricular arrhythmias in non-ischemic cardiomyopathy present significant clinical challenges due to diverse etiologies and complex arrhythmogenic substrates differing from ischemic heart disease.
This review highlights recent advancements in imaging, mapping, and ablative therapies for managing complex ventricular arrhythmias in patients with non-ischemic cardiomyopathy.
Ventricular arrhythmias (VAs) in non-ischemic cardiomyopathy (NICM) present significant clinical challenges due to their diverse etiologies and complex arrhythmogenic substrates, which differ from those in ischemic heart disease. Recent advancements in imaging, electrophysiological mapping, and ablative therapy have improved the management of these arrhythmias. This review examines the spectrum of NICM subtypes, discussing their pathophysiology, prevalence, genetic determinants, and associated arrhythmias. It also explores contemporary ablative techniques, including epicardial, bipolar, and irrigated approaches, as well as emerging modalities such as stereotactic body radiation therapy (SBRT). The role of novel technologies, including high-resolution mapping and artificial intelligence, is considered in refining diagnosis and treatment. This article provides a comprehensive overview of current management strategies and discusses future directions in the treatment of VAs in NICM patients.
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Stanciulescu et al. (2025) conducted a review in Ventricular arrhythmias in non-ischemic cardiomyopathy. Ablative therapy and emerging modalities (SBRT, AI) was evaluated. Recent advancements in imaging, electrophysiological mapping, and ablative therapies, including SBRT and AI, have improved the management of ventricular arrhythmias in non-ischemic cardiomyopathy.
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