General involvement of hypoxia-inducible factor 1 in transcriptional response to hypoxia.

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1. 1A Nuclear Factor Induced by Hypoxia via De Novo Protein Synthesis Binds to the Human Erythropoietin Gene Enhancer at a Site Required for Transcriptional Activation1992 · 932 citations
2. 2Cell-type-specific and hypoxia-inducible expression of the human erythropoietin gene in transgenic mice.1991 · 257 citations
3. 3Regulation of the Erythropoietin Gene: Evidence That the Oxygen Sensor Is a Heme Protein1988 · 1,042 citations
4. 4Hypoxic induction of the human erythropoietin gene: cooperation between the promoter and enhancer, each of which contains steroid receptor response elements.1992 · 216 citations
5. 5Hypoxia induces endothelin gene expression and secretion in cultured human endothelium.1991 · 689 citations