What does this research mean for the field?

Blood replacement with packed red blood cells during major aortic reconstruction provides effective volume replacement without causing coagulopathy or clinically significant pulmonary dysfunction, comparable to whole blood. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

March 1, 1981Annals of SurgeryOpen Access

Whole Blood Versus Packed-cell Transfusions

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Why the study?

Does blood replacement with whole blood compared to packed cells improve hemodynamic and coagulation parameters in patients undergoing major aortic reconstructions?

Population

28 patients undergoing major aortic reconstructions

Comparison

Blood replacement with whole blood (WB) vs Blood replacement with packed cells (PRBC)

Design

RCT, prospectively randomized into two groups

Follow-up

3 days after operation

Authors

SSSteven R. ShackfordScripps Mercy Hospital RVRichard W. VirgilioColumbus State University RPRichard M. PetersThe University of Texas at Austin

Discussion

Member takes

Implication

Supports PRBC as effective volume replacement without coagulopathy in aortic surgery; extends evidence for component therapy over whole blood in major reconstructions.

Structured PICO

Does blood replacement with whole blood compared to packed cells improve hemodynamic and coagulation parameters in patients undergoing major aortic reconstructions?

Population

28 patients undergoing major aortic reconstructions

Intervention

Blood replacement with whole blood (WB)

Comparator

Blood replacement with packed cells (PRBC)

Outcome

Hemodynamic and coagulation parameters including cardiac index (CI), pulmonary capillary wedge pressure (PCWP), intrapulmonary shunt (Qs/Qt), serum colloid osmotic pressure (COP), platelets, prothrombin time (PT), partial thromboplastin time (PTT), and fibrinogen measured before, during, and for three days after operationsurrogate

Blood replacement with packed red cells provides effective volume replacement without producing coagulopathy or significant pulmonary dysfunction compared to whole blood in major aortic reconstructions.

Cite This Study

Shackford et al. (1981) studied this question.

synapsesocial.com/papers/6a159b5da2352da34782ae84 https://doi.org/10.1097/00000658-198103000-00015

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Implication

Supports PRBC as effective volume replacement without coagulopathy in aortic surgery; extends evidence for component therapy over whole blood in major reconstructions.

Whole Blood Versus Packed-cell Transfusions

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Whole Blood Versus Packed-cell Transfusions

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider