Key result
Immune cells drive chronic vascular inflammation to both promote and inhibit atherosclerosis development.
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Atherosclerosis is a chronic inflammatory disease driven by various immune cells that either promote or inhibit its development.
Atherosclerosis, previously regarded as a lipid storage disease, has now been classified as a chronic inflammatory disease. The hardening of arterial vessels characterizes atherosclerosis due to the accumulation of lipids in the arterial walls, eliciting an inflammatory response. The development of atherosclerosis occurs in various stages and is facilitated by many clinical factors, such as hypertension, hyperlipidemia, and inflammatory status. A large arsenal of cells has been implicated in its development. This review will summarize the phases of atherosclerotic formation and all the cells involved in either promoting or inhibiting its development.
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Khalaf et al. (2025) conducted a review in Atherosclerosis. Atherosclerosis is characterized as a chronic inflammatory disease involving a large arsenal of immune cells that either promote or inhibit its development.
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