Key result
Higher baseline-pool local impedance produces ~29% deeper and wider ablation lesions in a porcine model.
Why the study?
The impact of baseline-pool local impedance on lesion size remains unclear.
Does baseline-pool local impedance affect lesion size during ablation using a local impedance-sensing catheter in a porcine model?
Does baseline-pool local impedance affect lesion size during ablation using a local impedance-sensing catheter in a porcine model?
In a porcine model, lesion size decreased with lower baseline-pool local impedance, suggesting adjusted %LI drops may better predict lesion formation.
Baseline impedance influences lesion size in this porcine model; hypothesis-generating for clinical impedance-guided ablation.
Background Impact of baseline‐pool local impedance (BP‐LI) on the lesion size remains unclear. Methods Lesion size in the porcine left ventricular myocardium was evaluated using the STABLEPOINT™ catheter across various ablation settings and BP‐LIs (100, 140, and 180 ohms). Results A total of 184 lesions were created with different durations (15/30/60 s) at 30 watts or with different powers (30/40/50 W) for 15 s. Lesion depth became deeper (2.8/3.0/3.6 mm at 15 s; p = .007, 4.0/4.9/4.6 mm at 30 s; p = .004, and 5.9/5.5/5.2 mm at 60 s; p = .710) and lesion width wider (5.8/6.3/7.6 mm at 15 s; p = .002, 7.0/8.9/8.9 mm at 30 s; p < .001, and 10.5/9.4/10.5 mm at 60 s; p = .262) as the BP‐LI increased under 30 W. Similarly, the lesion depth became significantly deeper (2.1/3.4/3.7 mm at 30 W; p < .001, 3.5/4.6/4.6 mm at 40 W; p < .001, and 4.1/4.7/5.2 mm at 50 W; p = .002) and lesion width broader (5.1/6.9/7.0 mm at 30 W; p < .001, 7.0/7.9/8.1 mm at 40 W; p = .004, and 7.7/8.2/9.6 mm at 50 W; p < .001, respectively) as the BP‐LI increased with a 15‐s ablation. The relationship between the LI drop and lesion size varied with the different BP‐LIs. Adjusted %LI drops (absolute LI drop divided by the BP‐LI) minimized the differences between the LI values and lesion formation among the three BP‐LIs. Conclusion Lesion size decreased with lower BP‐LI, and the relationship between the LI drops and lesion formation varied across the different BP‐LIs. Adjusted %LI drops may serve as a more reliable parameter for predicting the lesion formation.
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Fukaya et al. (2025) studied Catheter ablation lesion formation. STABLEPOINT catheter ablation vs. Different baseline-pool local impedances (100, 140, 180 ohms) was evaluated on Lesion depth and width. Higher baseline-pool local impedance (180 vs 100 ohms) resulted in significantly deeper (3.6 vs 2.8 mm; p=0.007) and wider (7.6 vs 5.8 mm; p=0.002) lesions during 30W/15s ablation in a porcine model.
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