Risk based ranking of prioritized pesticides: where the exposome meets comparative toxicogenomics

This is the authors' abstract. We don't add key points for this paper.

) samples and analyzed their association across various populations and seasons. Our study focused on eight key pesticides with high exposure risks through dust ingestion and identified risks to 12 human body systems. Notably, cypermethrin and deltamethrin were related to increased risks of asthma, lung injury, pulmonary fibrosis, and lung tumors, particularly affecting the respiratory system. A cross-regional analysis involving 13 countries using RDES and databases such as Tox21 and CTD, revealed that exposure-based health risks were highest in Korea, followed by Costa Rica/South Africa, China, Belgium, Poland, and the USA. This study introduced a standardized framework for Exposure Source identification-Internal Exposure assessment-Health Risk prediction (ESIEHR), for assessing emerging pollutants and highlights the necessity for targeted interventions to reduce health impacts.