Why the study?
Does flecainide alter the electrophysiological characteristics of human atrial fibres?
Does flecainide alter the electrophysiological characteristics of human atrial fibres?
The effects of flecainide on human atrial repolarisation depend on the shape of the action potential and are more pronounced in cells with a plateau where transient outward currents are active.
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Atrial AP morphology modulates flecainide effects on repolarization; leaves open translation to human AF models.
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Grand et al. (1990) studied this question.
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