What question did this study set out to answer?

To establish and calculate standardized reference change values (RCVs) based on biological variation to guide the objective interpretation of serial laboratory test results.

May 14, 2004Scandinavian Journal of Clinical and Laboratory Investigation

The reference change value: a proposal to interpret laboratory reports in serial testing based on biological variation

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Authors

CRCarmen RicósSpanish Society of Family and Community Medicine FCFernando CavaUniversidad Complutense de Madrid JGJosé Vicene Garcı́a-LarioHospital Universitario Virgen de las Nieves

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Implication

Database analysis establishes reference change values for 261 laboratory analytes, providing an objective framework to detect clinically meaningful changes during serial patient testing.

Key Points

To establish and calculate standardized reference change values (RCVs) based on biological variation to guide the objective interpretation of serial laboratory test results.
Compiled biological variation data across 191 published studies covering various laboratory analytes.
Calculated RCVs for 261 analytes using Harris's formula at a 95% probability level.
Defined analytical imprecision specifications as half of the within-subject biological variation.
Standardized RCV criteria were successfully generated for 261 distinct clinical analytes.
Provided an objective, biology-based framework for clinical laboratories to distinguish true pathological shifts from normal biological and analytical variation in serial testing.

Cite This Study

Ricós et al. (2004) studied this question.

synapsesocial.com/papers/6a15b68337103a4337a0197d https://doi.org/10.1080/00365510410004885

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Implication

Database analysis establishes reference change values for 261 laboratory analytes, providing an objective framework to detect clinically meaningful changes during serial patient testing.

The reference change value: a proposal to interpret laboratory reports in serial testing based on biological variation

Discussion

Member takes

Implication

Key Points

Cite This Study

The reference change value: a proposal to interpret laboratory reports in serial testing based on biological variation

Discussion

Member takes

Implication

Key Points

Cite This Study

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