Key result
In patient-specific computational models of persistent atrial fibrillation, reentrant drivers consistently localized to fibrotic boundaries, but specific anchoring sites were sensitive to ±10% variations in action potential duration and conduction velocity.
Population
Computational models of fibrotic atria derived from clinical imaging of patients with persistent atrial…
Design
Preclinical
Authors
Loading...
May caution against simulation-only ablation targeting in persistent AF; leaves open validation of fibrotic boundary predictions across parameter ranges.
Personalized ablation strategies based solely on simulation-predicted reentrant driver trajectories from non-invasive imaging may be insufficient due to high uncertainty from electrophysiological parameter variability.
Deng et al. (2017) studied Persistent atrial fibrillation (n=12). Variability in action potential duration (APD) and conduction velocity (CV) vs. Average human AF electrophysiology (EP avg) was evaluated on Reentrant driver (RD) localization and overlap with EP avg targets. In patient-specific computational models of persistent atrial fibrillation, reentrant drivers consistently localized to fibrotic boundaries, but specific anchoring sites were sensitive to ±10% variations in action potential duration and conduction velocity.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: