Key result
Depression at discharge was present in 9.6% of MI patients and showed a significant trend for increasing 1-year mortality with increasing severity of the depressive state (P=0.028).
Why the study?
Is depression associated with increased 1-year mortality in patients with myocardial infarction?
Cohort (n=763)
Is depression associated with increased 1-year mortality in patients with myocardial infarction?
p-value: p=0.028
While depression overall was not an independent predictor of 1-year mortality post-MI, increasing severity of depression was associated with higher mortality, particularly in patients with non-Q-wave infarction.
Severity of post-MI depression associated with 1-year mortality; leaves open whether screening or treatment alters outcomes.
OBJECTIVE: To estimate the prevalence of ICD-10 depression using a self-reported questionnaire and to examine if depression is associated with increased 1-year mortality in patients with myocardial infarction (MI). METHOD: In total, 763 MI-patients completed the Major Depression Inventory at discharge. Information from hospital notes was collected and patients were followed 1 year for re-admission and mortality through national registries. RESULTS: Seventy-three patients (9.6%) were depressed at discharge. Depression was not a significant independent predictor of mortality; however, there was a significant trend for increasing mortality with increasing severity of the depressive state (P = 0.028). All mortality among depressed patients was in patients with non-Q-wave infarction. CONCLUSION: Ten per cent of MI-patients fulfilled diagnostic criteria for depression at discharge. There was a significant trend for increasing mortality with increasing severity of the depressive episode. All mortality among depressed patients was seen in patients with non-Q-wave infarction. These findings indicate future studies in selected subgroups of MI-patients.
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Sørensen et al. (2006) conducted a cohort in Myocardial infarction (n=763). Depression vs. No depression was evaluated on 1-year mortality (p=0.028). Depression at discharge was present in 9.6% of MI patients and showed a significant trend for increasing 1-year mortality with increasing severity of the depressive state (P=0.028).
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