3D single breath-hold LGE using supplemental oxygen and hyperventilation reduced total scan time compared to free-breathing acquisition (35 vs 85 s; P<0.001) with similar image quality.
Observational (n=23)
Single-blind (outcome assessors)
Does 3D single breath-hold LGE with supplemental oxygen and hyperventilation reduce scan time while maintaining image quality compared to free-breathing acquisition?
Supplemental oxygenation and hyperventilation enable single breath-hold 3D LGE imaging, significantly reducing scan time without compromising image quality.
Absolute Event Rate: 35% vs 85%
p-value: p=<0.001
PURPOSE: To evaluate the feasibility of three-dimensional (3D) single breath-hold late gadolinium enhancement (LGE) of the left ventricle (LV) using supplemental oxygen and hyperventilation and compressed-sensing acceleration. METHODS: Breath-hold metrics breath-hold duration, diaphragmatic/LV position drift, and maximum variation of R wave to R wave (RR) interval without and with supplemental oxygen and hyperventilation were assessed in healthy adult subjects using a real-time single shot acquisition. Ten healthy subjects and 13 patients then underwent assessment of the proposed 3D breath-hold LGE acquisition (field of view = 320 × 320 × 100 mm(3) , resolution = 1.6 × 1.6 × 5.0 mm(3) , acceleration rate of 4) and a free-breathing acquisition with right hemidiaphragm navigator (NAV) respiratory gating. Semiquantitative grading of overall image quality, motion artifact, myocardial nulling, and diagnostic value was performed by consensus of two blinded observers. RESULTS: Supplemental oxygenation and hyperventilation increased the breath-hold duration (35 ± 11 s to 58 ± 21 s; P 0.01). LGE images were of similar quality when compared with free-breathing acquisitions, but with reduced total scan time (85 ± 22 s to 35 ± 6 s; P < 0.001). CONCLUSIONS: Supplemental oxygenation and hyperventilation allow for prolonged breath-holding and enable single breath-hold 3D accelerated LGE with similar image quality as free breathing with NAV.
Roujol et al. (Tue,) conducted a observational in Patients requiring cardiac MRI and healthy volunteers (n=23). 3D single breath-hold LGE with supplemental oxygen and hyperventilation vs. Free-breathing LGE with NAV respiratory gating was evaluated on Total scan time (seconds) (p=<0.001). 3D single breath-hold LGE using supplemental oxygen and hyperventilation reduced total scan time compared to free-breathing acquisition (35 vs 85 s; P<0.001) with similar image quality.