Key result
Microelectrode arrays successfully detect mechanical beating and synchronous electrical signals in in-vitro myocardial tissue.
Microelectrode arrays can effectively map electrical signal propagation and conduction in in-vitro myocardial tissue slices.
Cardiac electrophysiology and drug study on the cardiomyocyte culture make great progress. In the present study microelectrode array (MEA) was used to detect the mechanically beatings of the whole heart and the cardiac tissue slice in vitro with multi-sites. The experiment results show that the cardiac tissues in vitro can keep good status and favorable beating. Additionally, the cardiac tissue slices can maintain the structure and characteristics of the whole heart, which is accordant to the excitation-contraction coupling mechanism. Using this sensing technology based on the myocardial tissues, we synchronously obtained the electrical signals of different positions of myocardial tissue, which is helpful to judge the direction of myocardial electrical signal propagation and conduction.
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Chen et al. (2022) studied Cardiac electrophysiology. Microelectrode array (MEA) sensing technology was evaluated on Detection of mechanical beatings and electrical signals of myocardial tissue. Microelectrode array sensing technology successfully detected mechanical beatings and synchronously obtained electrical signals from different positions of in-vitro myocardial tissue.
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