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February 1, 1974Circulation Research

Distribution of the Coronary Blood Flow across the Canine Heart Wall during Systole

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Population

Canine heart model

Design

Preclinical

Authors

JDJames M. DowneyUniversité Claude Bernard Lyon 1EKEdward S. KirkUniversity of Illinois Urbana-Champaign

Discussion

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Implication

Indicates intramyocardial pressure restricts inner LV perfusion in dogs; leaves open translation to human ischemia risk and flow regulation.

Structured PICO

P
Population
Canine heart model
I
Intervention
Bolus of 86 Rb introduced into the coronary circulation with perfusion limited to the periods of systole
O
Outcome
Transmural distribution of left coronary blood flow during systole measured by myocardial uptake of 86 Rbsurrogate

The study demonstrates a transmural gradient of systolic coronary blood flow in the canine heart, indicating that intramyocardial pressure limits flow via a vascular sluice mechanism.

Cite This Study

Downey et al. (1974) studied this question.

synapsesocial.com/papers/6a15c28d5347fbb173a03c15https://doi.org/10.1161/01.res.34.2.251
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Also Consider

Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Nonuniform distribution of blood flow and gradients of oxygen tension within the heart1964 · 251 citations
  2. 2An experimental and theoretical analysis of myocardial tissue pressure1964 · 198 citations
  3. 3Influence of the Rate of Coronary Plasma Flow on the Extraction of Rb 86 from Coronary Blood1959 · 61 citations