Key result
The Womersley-based approach provided more accurate estimates of blood flow rate at the peak instant with a lower mean error (8.2 ± 28.3 cm3/s) compared to the a priori approach (-19.1 ± 61.4 cm3/s).
Why the study?
Does the Womersley-based approach improve the accuracy of blood flow rate estimation compared to the a priori approach in healthy volunteers?
Observational (n=10)
No
Does the Womersley-based approach improve the accuracy of blood flow rate estimation compared to the a priori approach in healthy volunteers?
Absolute Event Rate: 8.2% vs -19.1%
A Womersley-based approach for estimating blood flow rate from maximum velocity is more accurate than traditional a priori assumptions, potentially improving clinical assessments like Coronary Flow Reserve.
Womersley-based estimates may refine noninvasive flow assessment; leaves open validation in patients and outcome impact.
In this work we carry out an in vivo validation of a method for estimating blood flow rate from the peak velocity, as it is usually done in single-wire Doppler catheter measurements. This method, originally proposed in [1] stems from the application of numerical analysis of the blood flow with Computational Fluid Dynamics (CFD) techniques. It proposes a new formula linking the maximum velocity and the flow rate, which, however, has the same practical cost of classical approaches based on a priori assumptions on the velocity profile. After the first clinical observations indicating the improved accuracy in flow rate estimates introduced by the new method discussed in [2, 3], in this paper we present an ad hoc in vivo validation, as firstly suggested in [4], still confirming the reliability of the new approach.
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Ponzini et al. (2009) conducted an observational in Healthy volunteers (n=10). Womersley-based approach vs. A priori approach was evaluated on Mean error in blood flow rate estimation compared to gold standard. The Womersley-based approach provided more accurate estimates of blood flow rate at the peak instant with a lower mean error (8.2 ± 28.3 cm3/s) compared to the a priori approach (-19.1 ± 61.4 cm3/s).
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