Key result
Mouse cardiac MyBPC binds actin filaments with an affinity of 4.3 ± 1.1 μM and a 1:1 molar ratio via a single, moderate affinity site localized to the C-terminal region.
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No immediate clinical implications for cardiomyopathies; leaves open further mapping of MyBPC-actin roles in cardiac sarcomeres.
Rybakova et al. (2010) studied this question. Mouse cardiac MyBPC binds actin filaments with an affinity of 4.3 ± 1.1 μM and a 1:1 molar ratio via a single, moderate affinity site localized to the C-terminal region.
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