Key result
HFpEF is linked to higher circulating 3-nitrotyrosine versus HFrEF and controls, indicating intensified oxidative stress.
Why the study?
The study aimed to evaluate and compare plasma levels of 3-nitrotyrosine, a marker of nitrosative/oxidative stress, and myeloperoxidase, an indicator of inflammation, between HFpEF and HFrEF.
Do plasma levels of 3-NT and MPO differ between patients with HFpEF, HFrEF, and controls?
Observational (n=90)
Do plasma levels of 3-NT and MPO differ between patients with HFpEF, HFrEF, and controls?
Nitrosative/oxidative stress, as measured by 3-NT, is significantly intensified in HFpEF compared to HFrEF and controls, highlighting distinct pathophysiological mechanisms between the heart failure subtypes.
HFpEF-linked 3-NT elevation highlights subtype-specific oxidative stress; hypothesis-generating and should not yet change practice.
Heart failure (HF) is a complex syndrome characterized by impaired cardiac function. Two common subtypes of HF include heart failure with preserved ejection fraction (HFpEF) and heart failure with reduced ejection fraction (HFrEF). In this study, we aimed to evaluate and compare the plasma levels of 3-nitrotyrosine (3-NT)-as a marker of nitrosative/oxidative stress and myeloperoxidase (MPO)-as an indicator of inflammation between HFpEF and HFrEF. Twenty-seven patients diagnosed with HFpEF and twenty-two with HFrEF were enrolled in this study. Additionally, forty-one patients were recruited for the control group. An echocardiographic assessment was conducted, followed by the collection of blood samples from all participants. Subsequently, the levels of 3-NT and MPO were quantified using the ELISA method. Comprehensive clinical characteristics and medical histories were obtained. Circulating levels of 3-NT were significantly higher in the HFpEF patients than in the control and the HFrEF groups. Nitrosative/oxidative stress is significantly intensified in HFpEF but not in HFrEF.
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Momot et al. (2023) conducted an observational in Heart failure with preserved and reduced ejection fraction (n=90). Biomarker assessment (3-NT and MPO) vs. Control group and HFrEF group was evaluated on Plasma levels of 3-nitrotyrosine (3-NT) and myeloperoxidase (MPO). Circulating levels of 3-nitrotyrosine were significantly higher in HFpEF patients than in control and HFrEF groups, indicating intensified nitrosative/oxidative stress in HFpEF.
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