Signal Fingerprinting as a Novel Diagnostic Tool to Identify Conduction Inhomogeneity

Figures

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  FIGURE 1. The upper left panel demonstrates a schematic presentation of the 192-unipolar electrode array and the projection of this array on a schematic posterior view of the atria. The lower left panel demonstrates typical examples of the different types of EGMs classified in this study. The right panel shows a color-coded activation map; isochrones (thin black lines) are drawn at 10 ms intervals and the black arrow indicates wavefront propagation. IVC, inferior vena cava; SVC, superior vena cava; RA, right atrium; BB, Bachmann’s bundle; LA, left atrium; PV(A), pulmonary vein (area); EGM, electrogram; SP, single potential; SDP, short double potential; LDP, long double potential; FP, fractionated potential.

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  FIGURE 2. The upper left panel shows the proportion of long double and fractionated potentials for each individual patient; patients are ranked according to an increase in fractionation. The lower panel demonstrates typical examples of color-coded signal maps from four different patients, showing the proportion of the different EGM types at the various recording sites. These maps correspond to the patients marked in the graph by colored dots (green, yellow, orange, and red). FP, fractionated potential; EGM, electrogram; LDP, long double potential; SDP, short double potential; SP, single potential.

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  FIGURE 3. Median R/S ratios, voltage, and proportion of low-voltage areas plotted for each individual patient; patients are ranked according to increasing values of these parameters. The median value of each parameter is indicated by the horizontal line.

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  FIGURE 4. Relative incidence of fractionated potentials at Bachmann’s bundle of a subset of 123 patients who were mapped with the 192-electrode array. LA, left atrium; RA, right atrium.

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  FIGURE 5. Histograms of the relative frequency distribution of all voltages (upper), R/S ratios (middle), and fractionation durations (lower) recorded at the right atrium (blue), Bachmann’s bundle (orange), pulmonary vein area (green), and left atrium (red). Median voltage values are indicated by the black dotted lines. All histograms are subdivided and stacked according to the potential type classification (SP, SDP, LDP, or FP). SP, single potential; SDP, short double potential; LDP, long double potential; FP, fractionated potential.

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  FIGURE 6. Boxplots depicting the median value of the EGM features for each region separately. Statistical significance for comparison between all other atrial regions is indicated by an asterisk. SP, single potential; SDP, short double potential; LDP, long double potential; FP, fractionated potential; FD, fractionation duration.

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  FIGURE 7. Two examples of a signal fingerprint obtained from one patient with a low and one with a high degree of inhomogeneity in conduction. The upper panels show the distribution of potential types of the entire (left, pie plot) and for each region separately (right, stacked bars). The middle left plot shows the R/S ratio distribution of all SPs of the entire atrium. The middle center bar plot displays the number of low-voltage potentials plotted for each region separately. The middle right plot shows the distribution of voltages (mV) of SPs (green), SDPs (yellow), LDPs (orange), and FPs (red) from all atrial regions. The lower panel displays the distribution of fractionation duration (ms) for LDPs (left) and FPs (right). SP, single potential; SDP, short double potential; LDP, long double potential; FP, fractionated potential; FD, fractionation duration.