Key result
Inhaled 12% CO2 reduces cerebral hypoperfusion volume vs room air in rats with acute ischemic stroke.
Why the study?
The vasodilatory response to inhaled CO2 occurs in the acute stroke ischemic penumbra and may be a potential therapeutic modality.
Does inhaled CO2 reduce the volume of cerebral hypoperfusion in a rat model of acute ischemic stroke?
Does inhaled CO2 reduce the volume of cerebral hypoperfusion in a rat model of acute ischemic stroke?
p-value: p=0.004
Inhaled 12% CO2 significantly reduced the volume of cerebral hypoperfusion in a rat model of acute ischemic stroke, suggesting a potential therapeutic modality to maintain the ischemic penumbra.
Not ready for clinical use in stroke; leaves open whether inhaled CO2 merits translational trials to preserve penumbra.
Purpose The vasodilatory response to inhaled CO 2 occurs in the acute stroke ischemic penumbra and may be a potential therapeutic modality. Methods Twenty-two Sprague-Dawley rats were subjected to 90-min occlusion of the M2 segment of the middle cerebral artery (M2CAO) by endovascular technique. The animals were administered different C02 concentrations and scanned serially with 9.4 T MRI. Infarct tissue was determined by diffusion-weighted imaging (DWI) and hypoperfused tissue was determined by arterial spin labeling (PWI). Results 4 animals were administered room air (RA)+ 6% CO 2 (group 1), 6 animals RA+12% CO 2 (Group 2) and 4 animals only RA (group 3). In the rats with CO 2 administered (groups 1 and 2), the DWI lesion to cerebral hypoperfusion volume ratio (SD) at pre-CO 2 administration, was 0.145(0.168), which increased to 0.708(0.731) during CO 2 administration and reduced to 0.533(0.527) post-CO 2 administration. In 9 of 10 rats the hypoperfused volume decreased when CO 2 was administered. When CO 2 was stopped the hypoperfused volume became larger again. Administration of RA+12% CO 2 (Group 2) decreased the volume of CBF hypoperfusion significantly compared to the control group (95%CI: 0.084 ± 0.0213, p = 0.004). Conclusion Inhaled CO 2 appears to reduce the size of the hypoperfused tissue volume during acute stroke and may be a potential modality for treatment of acute ischemic stroke. These findings will nonetheless need to be validated in a larger cohort in other centers.
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Yeo et al. (2022) studied Acute ischemic stroke (n=22). Inhaled Carbon Dioxide (CO2) vs. Room air was evaluated on Decrease in volume of cerebral blood flow hypoperfusion (95% CI 0.034-0.133, p=0.004). Administration of 12% inhaled carbon dioxide significantly decreased the volume of cerebral blood flow hypoperfusion compared to room air in a rat model of acute ischemic stroke.
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