Key result
Preoperative VE/VCO2 slope and PetCO2 show similar accuracy predicting major cardiopulmonary complications after esophageal resection.
Why the study?
Research on the utility of PetCO2 for risk stratification in major abdominal surgery is limited, despite its relation to ventilation/perfusion mismatch.
Do preoperative VE/VCO2 slope and PetCO2 predict major cardiopulmonary complications or death following major abdominal cancer surgery?
Cohort (n=116)
Do preoperative VE/VCO2 slope and PetCO2 predict major cardiopulmonary complications or death following major abdominal cancer surgery?
Answers are grounded in this paper and cite their sources.
Preoperative PetCO2 is a simple and effective alternative to VE/VCO2 slope for predicting major cardiopulmonary complications or death after oesophageal cancer surgery.
Background Ventilation as a function of elimination of CO 2 during incremental exercise (VE/VCO 2 slope) has been shown to be a valuable predictor of complications and death after major non‐cardiac surgery. VE/VCO 2 slope and partial pressure of end‐tidal carbon dioxide (PetCO 2 ) are both affected by ventilation/perfusion mismatch, but research on the utility of PetCO 2 for risk stratification in major abdominal surgery is limited. Aim We aimed to determine the correlation between VE/VCO 2 slope and PetCO 2 measured during preoperative cardiopulmonary exercise testing (CPET) and its association with major cardiopulmonary complications (MCPCs) or death following oesophageal and other major abdominal cancer surgeries. Method In a retrospective cohort of 116 patients undergoing preoperative CPET 2008–2023, VE/VCO 2 slope and PetCO 2 (kPa) were recorded. The main outcome was MCPC during hospitalisation or death ≤90 days of surgery. We determined threshold values for each measure, corresponding to 90% specificity, using receiver operating characteristics analysis. Results A strong negative correlation was found between PetCO 2 after a 5‐minute warm‐up and VE/VCO 2 slope (Pearson r = −.88). In oesophagus cancer, VE/VCO 2 slope >38 and PetCO 2 < 4.1 kPa (30.8 mmHg) were both significant thresholds for the main outcome. For other major abdominal surgery patients, threshold analyses were non‐significant. The area under the curve to predict outcome was similar using VE/VCO 2 slope (0.70, 95% confidence interval 0.51–0.89) as compared to PetCO 2 (0.71, 0.53–0‐90). Conclusion Both preoperative VE/VCO 2 slope and PetCO 2 could identify subjects with a very high risk of complications following oesophageal resection, with similar prognostic utility. PetCO 2 can be measured with simpler equipment and could therefore be useful when CPET is not available.
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Stark et al. (2024) conducted a cohort in Oesophageal and other major abdominal cancer (n=116). VE/VCO2 slope and PetCO2 was evaluated on Major cardiopulmonary complications (MCPCs) during hospitalisation or death ≤90 days of surgery (AUC 0.70 (VE/VCO2 slope) vs AUC 0.71 (PetCO2), 95% CI 0.51-0.89 vs 0.53-0.90). Preoperative VE/VCO2 slope and PetCO2 demonstrated similar prognostic utility for predicting major cardiopulmonary complications or death following oesophageal resection.
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