Key result
Ganglionectomy in mice alters hypoxic ventilation vs sympathetic transection, suggesting direct SCG activation.
Hypoxic gas challenge may directly activate subpopulations of superior cervical ganglia cells independently of preganglionic cervical sympathetic chain drive.
Hypothesis-generating for direct SCG modulation of hypoxia; leaves open human translation and clinical relevance.
We present data showing that the ventilatory responses elicited by a hypoxic gas challenge in male C57BL6 mice with bilateral superior cervical ganglionectomy are not equivalent to those reported for mice with bilateral transection of the cervical sympathetic chain. These data suggest that hypoxic gas challenge may directly activate subpopulations of superior cervical ganglia (SCG) cells, including small intensely fluorescent (SIF) cells and/or principal SCG neurons, independently of preganglionic cervical sympathetic chain drive.
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Getsy et al. (2021) studied Hypoxia. Bilateral superior cervical ganglionectomy vs. Bilateral transection of the cervical sympathetic chain was evaluated on Ventilatory responses elicited by a hypoxic gas challenge. Bilateral superior cervical ganglionectomy in male mice produced ventilatory responses to hypoxia distinct from cervical sympathetic chain transection, suggesting direct SCG activation.
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